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Xigduo (5mg/tab-1000mg/tab Tablets)
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$105.00
Xigduo is a combination oral medication used to improve blood sugar control in adults with type 2 diabetes. It contains dapagliflozin, which helps the kidneys remove excess glucose through urine, and metformin, which reduces glucose production in the liver and improves insulin sensitivity. Taken twice daily, Xigduo offers a powerful, dual-action approach to managing blood sugar levels when used alongside diet and exercise.
Xigduo XR – Comprehensive, Once‑Daily Dual Therapy for Type 2 Diabetes
Managing blood sugar effectively is essential for maintaining health and preventing complications in adults with type 2 diabetes. Xigduo XR offers a powerful, once‑daily combination treatment—pairing metformin, a time‑tested cornerstone of diabetes care, with dapagliflozin, an SGLT2 inhibitor that helps eliminate excess glucose through the kidneys. Together, these two medications work in synergy to improve glycemic control, support weight management, and promote cardiovascular and renal health. At Fit Life Pharmacy, we provide authentic Xigduo XR formulations with expert guidance, competitive pricing, and convenient refill options to help you take control of your diabetes journey.
What Is Xigduo XR?
Xigduo XR is an extended‑release oral tablet that combines:
- Metformin Hydrochloride Extended‑Release: A biguanide that decreases hepatic glucose production and improves insulin sensitivity in muscle and fat tissues.
- Dapagliflozin: An SGLT2 inhibitor that blocks glucose reabsorption in the kidneys, allowing excess sugar to be excreted via urine.
Each tablet comes in two strengths: 5 mg dapagliflozin / 500 mg metformin XR, or 10 mg dapagliflozin / 1,000 mg metformin XR. Taken once daily with the morning meal, Xigduo XR delivers sustained blood sugar control over 24 hours.
Why a Dual‑Mechanism Approach Matters
Type 2 diabetes involves both impaired insulin response and excessive glucose production and reabsorption. By combining metformin’s action on the liver and peripheral tissues with dapagliflozin’s renal glucose excretion, Xigduo XR targets four key pathophysiological defects:
- Hepatic Glucose Output: Metformin reduces the liver’s overproduction of glucose, especially overnight and between meals.
- Insulin Sensitivity: Metformin enhances insulin’s effectiveness in muscle and fat cells, improving uptake of circulating glucose.
- Renal Glucose Reabsorption: Dapagliflozin inhibits SGLT2 transporters in the proximal renal tubules, preventing glucose from re‑entering the bloodstream.
- Glucose Excretion: Excess filtered glucose is lost through urine, reducing blood sugar and potentially leading to modest weight loss.
This complementary dual‑mechanism provides broader and more durable glycemic control than either agent alone, with the convenience of a single daily tablet.
Key Benefits of Xigduo XR
Improved Glycemic Control
Clinical trials demonstrate that Xigduo XR significantly reduces A1C levels—often by 1.2–1.8% from baseline—when added to diet, exercise, or other antidiabetic regimens.
Weight Management
While metformin is weight‑neutral or associated with mild loss, dapagliflozin promotes a loss of excess calories via urinary glucose excretion. Together in Xigduo XR, patients commonly experience gradual, sustainable weight reduction, which further enhances insulin sensitivity and overall health.
Blood Pressure Reduction
Dapagliflozin’s mild diuretic effect helps decrease systolic blood pressure by 3–5 mm Hg, contributing to cardiovascular risk reduction without additional antihypertensive therapy for many patients.
Cardiovascular and Renal Protection
SGLT2 inhibitors like dapagliflozin have demonstrated benefits in reducing hospitalization for heart failure and slowing progression of diabetic kidney disease. Xigduo XR inherits these protective effects, making it a compelling option for patients with cardiovascular or renal comorbidities.
Once‑Daily Convenience
Extended‑release metformin and SGLT2 inhibitor dapagliflozin combine into a single tablet taken once a day, simplifying medication schedules and improving adherence compared to multiple daily doses.
Indications: Who Should Use Xigduo XR?
Xigduo XR is approved for adults with type 2 diabetes to improve glycemic control when:
- Diet and exercise alone are insufficient.
- Patients need combination therapy to achieve target A1C.
- There is a desire to minimize pill burden and enhance adherence.
- Comorbid cardiovascular disease or early diabetic kidney disease is present.
It may be used as initial therapy in patients with A1C ≥ 7.5% when metformin alone is unlikely to achieve adequate control, or added to existing metformin therapy when additional glucose‑lowering is required.
How to Take Xigduo XR
Dosage
- Start with one 5 mg/500 mg tablet daily with the first meal to minimize gastrointestinal side effects from metformin.
- After 2–4 weeks, if tolerated and additional glycemic control is needed, the dose may be increased to one 10 mg/1,000 mg tablet daily.
Administration
- Swallow tablets whole. Do not crush, chew, or split.
- Take with food to reduce the risk of gastrointestinal upset from metformin.
- Stay well‑hydrated to mitigate potential diuretic effects of dapagliflozin.
Missed Dose
- If less than 12 hours have passed, take the missed dose with food when remembered.
- If more than 12 hours have passed, skip it and resume the regular schedule to avoid overlapping effects.
Regular monitoring of blood glucose and A1C—every 3 months until control is achieved, then every 6 months—is essential. Periodic assessment of kidney function (eGFR) and electrolytes is recommended.
Potential Side Effects
Xigduo XR is generally well tolerated, but side effects can occur. Common adverse events include:
- Genital Mycotic Infections: Increased glycosuria creates a favorable environment for yeast, leading to vaginal or penile infections. Good hygiene and prompt treatment can manage these.
- Urinary Tract Infections: Higher urinary glucose can predispose to UTIs. Drink plenty of water and report symptoms early.
- Gastrointestinal Symptoms: Nausea, diarrhea, or abdominal discomfort may occur initially due to metformin; usually transient and mitigated by gradual dose escalation and taking with food.
- Volume Depletion: Dapagliflozin’s diuretic effect may cause dizziness or hypotension, particularly in the elderly or those on antihypertensives. Monitor blood pressure and ensure adequate fluid intake.
Rare but serious risks:
- Ketoacidosis: SGLT2 inhibitors can rarely precipitate euglycemic diabetic ketoacidosis. Patients should be educated about recognizing symptoms—nausea, vomiting, abdominal pain, rapid breathing—and discontinue Xigduo XR if suspected, seeking immediate medical attention.
- Acute Kidney Injury: Volume depletion can compromise renal perfusion; caution and monitoring are warranted in patients with preexisting renal impairment.
- Lactic Acidosis: Extremely rare with metformin, but associated with significant hypoxia or renal failure. Confirm contraindications are excluded prior to initiation.
Prompt recognition and management of side effects preserve patient safety and treatment success.
Contraindications and Precautions
Xigduo XR should not be used by individuals with:
- Severe Renal Impairment (eGFR < 45 mL/min/1.73 m²) or on dialysis.
- Metabolic Acidosis or Diabetic Ketoacidosis.
- History of Serious Hypersensitivity to metformin, dapagliflozin, or tablet excipients.
Caution in patients with:
- Volume‑depleted states, elderly, or those on diuretics/RAAS inhibitors.
- Concurrent use of nephrotoxic drugs.
- Major surgery or acute illness: Temporarily hold Xigduo XR during acute hospitalizations or fluid loss risk.
Pregnancy and breastfeeding: Safety not established. Consult specialists for alternative therapies.
Drug Interactions
Xigduo XR can interact with several medications:
- Loop Diuretics: May increase risk of volume depletion.
- ACE Inhibitors/ARBs: Combined hypotensive effects; monitor blood pressure.
- Insulin or Sulfonylureas: Increased hypoglycemia risk; consider dose reduction of concomitant agents.
- Cationic Drugs (e.g., cimetidine): Compete for renal tubular secretion, may increase metformin levels; use cautiously.
Maintaining an up‑to‑date medication list and consulting a pharmacist helps prevent adverse interactions.
Comparing Xigduo XR with Other Combination Therapies
Several dual therapies address type 2 diabetes, but Xigduo XR stands out due to its unique pairing:
- Glucovance (glyburide/metformin): Combines sulfonylurea and metformin but carries higher hypoglycemia and weight gain risk.
- Janumet (sitagliptin/metformin): DPP‑4 inhibitor plus metformin offers weight neutrality and low hypoglycemia but lacks SGLT2‑mediated cardiovascular benefits.
- Steglujan (ertugliflozin/sitagliptin): SGLT2 + DPP‑4 inhibitor; weight loss and CV benefits but less robust hepatic/insulin sensitivity action compared to metformin.
Xigduo XR’s metformin backbone optimizes insulin sensitivity and hepatic control, while dapagliflozin adds renal glucose excretion and CV/kidney protection—delivering comprehensive benefits in a single pill.
Lifestyle Integration: Diet, Exercise, and Monitoring
While Xigduo XR is highly effective, optimal diabetes management also requires lifestyle measures:
- Balanced Diet: Focus on high‑fiber, low‑glycemic foods, lean proteins, and healthy fats. Coordinate carbohydrate intake with medication timing.
- Regular Physical Activity: Aim for 150 minutes/week of moderate exercise (e.g., walking, cycling) to enhance insulin sensitivity.
- Weight Management: Monitor weight trends; gradual weight loss improves glycemic control.
- Self‑Monitoring of Blood Glucose: Check fasting and postprandial levels regularly; use data to adjust diet, activity, and discuss dose changes with your provider.
- Blood Pressure and Lipid Control: Maintain targets to reduce macrovascular risk; consult your healthcare team for comprehensive CV risk management.
Empowering patients through education and support yields better long‑term outcomes.
Clinical Evidence
Landmark trials highlight Xigduo XR’s benefits:
- DECLARE‑TIMI 58: Dapagliflozin reduced hospitalization for heart failure by 27% and renal decline, regardless of baseline CV disease.
- MET‑DRIVE Study: Combining metformin XR with dapagliflozin lowered A1C by up to 1.5% with associated weight loss in treatment‑naïve patients.
- Real‑World Evidence: Observational data show higher persistence and fewer all‑cause hospitalizations compared to other dual therapies.
These outcomes underscore Xigduo XR’s role as a modern cornerstone for comprehensive diabetes care.
Cost‑Saving Programs and Insurance Support
Understanding medication costs is crucial. Fit Life Pharmacy offers:
- Manufacturer Copay Cards: Eligible patients can pay as little as $25/month.
- Formulary Navigation: We assist with insurance verification, prior authorizations, and appeals.
- Discount Generics: Generic dapagliflozin and metformin alternatives for standalone therapy when needed.
- Auto‑Refill Savings: Refill reminders and subscription discounts to ensure uninterrupted therapy.
Our pharmacists work with you to minimize out‑of‑pocket expenses and optimize access.
Patient Education and Resources
We provide comprehensive resources to support Xigduo XR users:
- Instructional Videos: Demonstrations on proper administration and storage.
- Printable Action Plans: Personalized schedules, blood glucose targets, and emergency contacts.
- Live Webinars: Diabetes management topics hosted by our clinical team.
- 24/7 Support Hotline: Pharmacist access for questions about dosing, side effects, or interactions.
Empowered patients achieve better adherence and outcomes.
Ordering Xigduo XR from Fit Life Pharmacy
Ordering Xigduo XR is simple:
- Online Portal: Secure checkout with insurance integration and savings card application.
- Mobile App: Refill requests and tracking on the go.
- Phone and Chat Support: Live help from our pharmacy specialists.
- Auto‑Refill Enrollment: Set refill intervals with text/email reminders to avoid gaps in therapy.
We ship discreetly, with tracking and signature options for peace of mind.
Frequently Asked Questions
What if I miss my Xigduo XR dose?
If within 12 hours, take it with your next meal. If beyond 12 hours, skip and resume routine the next day—do not double dose.
Can Xigduo XR cause dehydration?
Dapagliflozin’s diuretic effect can lead to volume depletion. Monitor fluid intake and blood pressure, especially if you’re on diuretics.
Is Xigduo XR safe for elderly patients?
Yes, but start at the lower dose (5 mg/500 mg) and monitor renal function and blood pressure more frequently.
How does Xigduo XR affect kidney function?
Properly hydrated patients often experience stable or improved renal outcomes, but caution in those with eGFR near the cutoff; consult your provider.
Can I combine Xigduo XR with insulin?
Yes, under medical supervision. Insulin dose reduction may be necessary to avoid hypoglycemia.
Conclusion
Xigduo XR represents a significant advancement in type 2 diabetes management by combining two complementary agents—metformin XR and dapagliflozin—into a single, once‑daily tablet. This powerful dual therapy addresses multiple defects in diabetes pathophysiology, delivering robust A1C reduction, weight loss, blood pressure improvement, and cardiovascular and renal protection.
At Fit Life Pharmacy, we’re dedicated to helping you harness the full potential of Xigduo XR through affordable pricing, personalized support, and seamless refill services. Take control of your diabetes with a treatment that simplifies your regimen without compromising on comprehensive care. Order Xigduo XR today and start your journey toward better blood sugar management and improved overall health.
Additional information
| Dosage | 60 tabs |
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